Neuroprotective effects of lactate and ketone bodies in acute brain injury Test - Ischémie Reperfusion, Métabolisme et Inflammation Stérile en Transplantation Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Journal of Cerebral Blood Flow and Metabolism Année : 2024

Neuroprotective effects of lactate and ketone bodies in acute brain injury Test

Résumé

The goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we frequently observe a strong decrease in glucose delivery and/or a glucose metabolic dysregulation following acute brain injury. In parallel, during the last decades, lactate and ketone bodies have been identified as potential alternative fuels to provide energy to the brain, both under physiological conditions and in case of glucose shortage. They are now viewed as integral parts of brain metabolism. In addition to their energetic role, experimental evidence also supports their neuroprotective properties after acute brain injury, regulating in particular intracranial pressure control, decreasing ischemic volume, and leading to an improvement in cognitive functions as well as survival. In this review, we present preclinical and clinical evidence exploring the mechanisms underlying their neuroprotective effects and identify research priorities for promoting lactate and ketone bodies use in brain injury.
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hal-04631544 , version 1 (02-07-2024)

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Guillaume Plourde, Hélène Roumes, Luc Pellerin, Laurent Suissa, Lorenz Hirt, et al.. Neuroprotective effects of lactate and ketone bodies in acute brain injury Test. Journal of Cerebral Blood Flow and Metabolism, 2024, 44 (7), pp.1078-1088. ⟨10.1177/0271678X241245486⟩. ⟨hal-04631544⟩
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