Synthesis of a New Poly(ε-caprolactone)-g-Chitosan Amphiphilic Graft Copolymer with a “Reverse” Structure - IMT Mines Alès Accéder directement au contenu
Article Dans Une Revue Macromolecular Rapid Communications Année : 2023

Synthesis of a New Poly(ε-caprolactone)-g-Chitosan Amphiphilic Graft Copolymer with a “Reverse” Structure

Résumé

Hydrophilic chitosan (CHT) and hydrophobic polyε-caprolactone (PCL) are well-known biocompatible and biodegradable polymers that have many applications in the biomedical and pharmaceutical fields. But the mixtures of these two compounds are considered incompatible, which makes them not very interesting. To avoid this problem and to further extend the properties of these homopolymers, the synthesis of a new graft copolymer, the fully biodegradable amphiphilic poly(ε-caprolactone-g-chitosan) (PCL-g-CHT) is described, with an unusual “reverse” structure formed by a PCL backbone with CHT grafts, unlike the “classic” CHT-g-PCL structure with a CHT main chain and PCL grafts. This copolymer is prepared via a copper-catalyzed 1,3-dipolar Huisgen cycloaddition between propargylated PCL (PCL-yne) and a new azido-chitosan (CHT-N3). In order to obtain an amphiphilic copolymer regardless of the pH, chitosan oligomers, soluble at any pH, are prepared and used. The amphiphilic PCL-g-CHT copolymer spontaneously self-assembles in water into nanomicelles that may incorporate hydrophobic drugs to give novel drug delivery systems.

Dates et versions

hal-04087673 , version 1 (03-05-2023)

Identifiants

Citer

Victor Delorme, Ghislain David, Stéphane Dejean, Julia Mouton, Xavier Garric, et al.. Synthesis of a New Poly(ε-caprolactone)-g-Chitosan Amphiphilic Graft Copolymer with a “Reverse” Structure. Macromolecular Rapid Communications, 2023, 44 (15), pp.2300156. ⟨10.1002/marc.202300156⟩. ⟨hal-04087673⟩
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