TRPV4 channels mediate the infrared laser-evoked response in sensory neurons - IMT Mines Alès Accéder directement au contenu
Article Dans Une Revue Journal of Neurophysiology Année : 2012

TRPV4 channels mediate the infrared laser-evoked response in sensory neurons

Résumé

Infrared laser irradiation has been established as an appropriate stimulus for primary sensory neurons under conditions where sensory receptor cells are impaired or lost. Yet, development of clinical applications has been impeded by lack of information about the molecular mechanisms underlying the laser-induced neural response. Here, we directly address this question through pharmacological characterization of the biological response evoked by midinfrared irradiation of isolated retinal and vestibular ganglion cells from rodents. Whole cell patch-clamp recordings reveal that both voltagegated calcium and sodium channels contribute to the laser-evoked neuronal voltage variations (LEVV). In addition, selective blockade of the LEVV by micromolar concentrations of ruthenium red and RN 1734 identifies thermosensitive transient receptor potential vanilloid channels as the primary effectors of the chain reaction triggered by midinfrared laser irradiation. These results have the potential to facilitate greatly the design of future prosthetic devices aimed at restoring neurosensory capacities in disabled patients.
Fichier principal
Vignette du fichier
trpv4-channels-mediate-the-infrared-laser-evoked-response-in-sensory-neurons.pdf (1.55 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01398845 , version 1 (13-03-2020)

Identifiants

Citer

Emmanuel Albert, Jean Michel Bec, Karim Chekroud, Cécile Travo, Sophie Gaboyard, et al.. TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. Journal of Neurophysiology, 2012, 107 (12), pp.3227-3234. ⟨10.1152/jn.00424.2011⟩. ⟨hal-01398845⟩
116 Consultations
258 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More