Choriocarcinoma in neonates and infants: A severe but curable disease - Institut Gustave Roussy
Article Dans Une Revue Pediatric Blood and Cancer Année : 2024

Choriocarcinoma in neonates and infants: A severe but curable disease

Résumé

Choriocarcinoma in neonates and infants (N-CC) is an extremely rare, but aggressive cancer, frequently observed with concomitant maternal disease. A retrospective, bi-national study of patients treated in France and Poland for infantile choriocarcinoma analysed eight cases of N-CC, median age of 6 weeks. All tumours were diffuse. Six patients received a platinum-based regimen, and five had delayed surgery on residual distant tumour sites. At the end of follow-up, four patients were in complete remission and four had died of the disease. In all but two cases, mothers had simultaneous metastatic choriocarcinoma. Even if the outcome remains poor, patients could be cured with multimodal therapy.
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hal-04822550 , version 1 (06-12-2024)

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Marie Pierre Castex, Joanna Stefanowicz, Laura Clement, Jadwiga Węcławek-Tompol, Frederic Hameury, et al.. Choriocarcinoma in neonates and infants: A severe but curable disease. Pediatric Blood and Cancer, 2024, 71 (8), ⟨10.1002/pbc.31124⟩. ⟨hal-04822550⟩
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