Data from a recent field campaign are used to analyze the nonstationary aspects of air-sea heat exchanges and marine atmospheric boundary layer (MABL) thermodynamics over the Gulf of Lion (GoL) in connection with synoptic forcing. The data set includes measurements made from a wide range of platforms (sea-borne, airborne, and space-borne) as well as three-dimensional atmospheric modeling. The analysis focuses on the 24 March 1998 Tramontane/Mistral event. It is shown that the nonstationary nature of the wind regime over the GoL was controlled by the multistage evolution of an Alpine lee cyclone over the Tyrrhenian Sea (between Sardinia and continental Italy). In the early stage (low at 1014 hPa) the Tramontane flow prevailed over the GoL. As the low deepened (1010 hPa), the prevailing wind regime shifted to a well-established Mistral that peaked around 1200 UTC. In the afternoon the Mistral was progressively disrupted by a strengthening outflow coming from the Ligurian Sea in response to the deepening low over the Tyrrhenian Sea (1008 hPa) and the channelling induced by the presence of the Apennine range (Italy) and the Alps. In the evening the Mistral was again well established over the GoL as the depression continued to deepen (1002 hPa) but moved to the southeast, reducing the influence of outflow from the Ligurian Sea on the flow over the GoL. The air-sea heat exchanges and the structure of the MABL over the GoL were observed to differ significantly between the established Mistral period and the disrupted Mistral period. In the latter period, surface latent and sensible heat fluxes were reduced by a factor of 2, on average. During that latter period, air-sea moisture exchanges were mainly driven by dynamics, whereas during the former period, both winds and vertical moisture gradients controlled moisture exchanges. The MABL was shallower during the latter period (0.7 km instead of 1.2 km) because of reduced surface turbulent heat fluxes and increased wind shear at the top of the MABL in connection with the outflow from the Ligurian Sea. In the period of established Mistral, gravity waves above the MABL were observed to have an influence on the MABL structure. In the perturbed Mistral case this influence was not observed. Over the GoL the ubiquitous presence of sheltered regions (i.e., regions of reduced wind speed in the MABL) in the lee of the three major mountain ranges surrounding the GoL (namely, the Pyrénées, the Massif Central, and the Alps) was shown to have an impact on surface turbulent heat fluxes. The position of these sheltered regions, which evolved with the synoptic conditions, was the key to a correct interpretation of multiplatform surface turbulent flux measurements made over the GoL on 24 March 1998.